Interestingly, a reference to the classical, such as Syracuse, of which there's a small town in Nebraska so named. Works best if misspelled or inappropriate, such as Eden for a town in the desert.
Other twists will come to you. I was once challenged by an easterner who took umbrage to me referring to Norfolk, NE, as 'north fork'. Claimed it should be 'nor folk'.
1) North Fork WAS the original pronunciation AND spelling, when an eastern postal official decided to change it (I'm a US liberal, but can understand a certain antipathy to DC interference),
2) having passed through the eastern US, and also hearing some Brit speakers, I'd have to say the common pronunciation is actually 'nah-fuk'.

As a youngster, I tried to imagine our North Fork was the one in The Rifleman. Then they got around to mentioning the territory...
That twist in speaking the name can add a world of color.
Cairo? On the Mississippi, and in Nebraska, it's 'kayr-row'.
Doug