I've yet to run into any bleeding issues with my pigma brand pens.
I have not sprayed them with an enamel yet though.
To a first estimate, if it'll move the ink, it'll probably move the paint as well! Most pen inks are pretty stable when hit with acrylic or enamel based materials. You'll hit problems if you use something heavily alcohol based or that involves a strong organic solvent (acetone, dichloromethane, ethyl acetate etc).