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Many people are now introduced to the mythos via games like Arkham Horror, where an encounter with something as nasty as a Chthonian is fairly commonplace, and a direct physical struggle with an elder god the end result of a typical game, rather than the rare and sanity-blasting experience it might have been in the heyday of the RPG.
I really want to see many of these creatures/factions used in a more complex ways than just "they all want to eat everyone's face and it's up to you to thwart them".
When they did come across a lot of deep ones at the culmination of a cargo cult scenario two of the players blew themselves and a number of deep ones up out of desparation.
First time I read that I missed the word "up".