For solo sci-first I've recently quite enjoyed the Rogue Planet ruleset, very simple and good fun to boot. Also the vagueness and guesstimations appeal to my sense of the absurd.
For big battles i plan to use Dragon Rampant but with a few alterations i.e. Space marines as elite heavy foot, I'll also go with reasonable guesses for ranged weapons as in rogue planet , I find DR to be pretty streamlined (and since I'm only competing against myself I don't need to worry about measuring).
I used to make reaction tables back in the day, but now I just work on the basis of what might the opposition do, and what would be cinematic and spectacular if it works out! I suppose the dice rolls add the random and unexpected elements.