SI YOU probably don't need this advice but just in case. When I've drilled perspex in the past, the drill sticks quite easily and can whip the sheet round if it's not jigged well, I was only doing small stuff 1" strips and just hand held it in my usual lazy way and it came as a bit of a shock when I nearly took my fingers off
It also cracks quite easily if thin sections but I've used 5 mm thick and it's bullet proof.