Hi,
The game should translate very well to non-NYC settings and I think it would work for any situation involving gang or tribal violence. I think it has been used for a 19th century Gangs of New York game and we've talked about using the rules to game 1960s British Mods vs Rockers or soccer hooligan violence. The figures for the game are themed around 1970s New York but the game isn't prescriptive and can be used with any figures.