Interesting list!
I wonder what rules the Vampire Slayers, Baker Street and Nemesis Criminal sets will get, as they're obviously not your generic factions... With the Order of Dragon rules announced, I'd say the Vampire Slayers could get their own rules too (though I still hope Van Helsing becomes a special character). The remaining two IMO should be just sets of special characters - though a band of Holmes' enemies sounds awesome.

If John Brown gets his own stats, he will probably have the same alignment as Queen Victoria. He's her servant after all.
The hound doesn't look that Evil to me, I think it could have all three alignments. Though it could get its own rules as the Black Dog or something similar.
The Baron should accompany the Monster and be Evil. Or maybe the Monster will be Neutral?