I have been neglecting Pulp Alley recently.
However, I've recently stumbled across the Brubaker/Phillips graphic novels, ahem, comics, Fatale.
It is gorgeously bleak stuff - Noir/Horror.
The central character, Josephine, would fit perfectly into a PA campaign spanning medieval, wild west, prohibition, WW2, 70s and modern. And all the time pursued by a seemingly human tentacle monster and Cultist followers.
Perfect!!