Please keep in mind that I have not watched the show yet (and may not)...
But a quick read of the premise on Wikipedia has the show about the North-West Fur trade, particularly about the Hudson's Bay company's monopoly....
Now if they are trying to give any real nods to history, that would likely put it in the 1780s or 1790s, almost exactly between the American Revolution and North American War of 1812.
The "promo" image of Mamoa with a bunch of antler handled knives convinced me early it would not be historical, and any nods to real history would be superficial at best. While antler handled knives are a historical thing, those forked antler handles would almost be more of a threat to the wearer of them than the potential target of them.
