I'm using an Expurgated version of the old SFB Designer's Edition with Cadet scaled ships - if that means anything to you. But I'm not married to a particular system. I'll probably try Full Thrust next.
The ships are kit bashes of the AMT from the 90s (Dreadnought), Johnny Lightning (D7), 3D Printed - Shapeways (Larson), 3D Printed - my own machine (D-23) and toys from Trek branded cookies (Bird of Prey) from the 90s.
It's taken me 20 years to find a Fed hull color I liked and learn how to do decals properly!
And to be able to 3D print too.