I toyed with the idea of a harvesting game. I even bought a few jawa sand crawlers to use as harvesters. My plan was to have a competion with each player as a different house and see who could harvest the most spice. Have small army on each side, a carry-all and a base. Players could try to gather spice and disrupt each others operations, freman spoiling raids, worms, Off world mercs, stealing other peoples stock piles.
Didn't get anywhere with it and I'm sure this is exactly the sort of thing the various Dune board games cover.